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3g, h). Ligelizumab binding forces the Cε3 domains right into a more symmetrical arrangement that closely aligns With all the IgE dimer twofold axis described from the Cε4 domains and that's incompatible with FcεRI binding. the power of ligelizumab to bind and dissociate the IgE-Fc3-4:FcεRI complexes indicates the complicated can dynamically access conformational states in which the secondary Cε3 area doesn't sterically block ligelizumab binding.
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